Radiation Induced Noncancerous Medical Conditions

RERF Website
Radiation Effects Research Foundation, Hiroshima.

[Minimal information has been extracted from the RERF website, indepth reports are available. See links below.]


Deaths due to noncancer disease

Recent analyses of data from the ABCC-Life Span Study (LSS) have revealed a statistically significant dose response for deaths from diseases other than cancer. The most recently published noncancer findings deal with follow-up from 1950 through 1985. The analyses are currently being extended through 1990. By the end of 1990, among the 50,113 LSS survivors with, 15,633 noncancer deaths had occurred, excluding deaths attributed to diseases of the blood, which are analyzed separately. Circulatory diseases account for nearly half of these deaths, with digestive diseases, including liver disease, and respiratory diseases each accounting for about 10% of the total.

Aside from diseases of the blood, the number of noncancer deaths associated with atomic-bomb radiation exposure is estimated to be about 140. The death rate following exposure to 0.2 Sv (the mean radiation dose for survivors with significant exposures) is increased by about 1% over normal rates. This is less than the death rate for solid cancer, for which the corresponding increases are 7% for men and 15% for women following atomic-bomb radiation exposure at age 30. The dose response may be nonlinear with low doses having a smaller effect than would be predicted from a simple linear dose-response model (see figure). The excess risks do not seem to be limited to any particular disease. In the absence of a known biological mechanism to account for these findings, it is important to consider whether the result might be due to biases or to misclassification of cancer deaths. Investigations have suggested that neither of these factors can explain the observed effect. In particular, studies of the incidence of myocardial infarction and chronic liver disease in the ABCC-RERF have shown radiation effects that are consistent with the mortality data.

A significant radiation dose response has been seen for noncancer blood diseases. About 35 of the 134 deaths are thought to be associated with radiation exposure. Some, but probably not all, of this excess may be misdiagnosed cases of leukemia.

When one looks at external causes, there is a small but statistically significant decrease in the likelihood of suicide as radiation dose increases.

References about this subject, available from RERF.

Shimizu Y, Kato H, Schull WJ, Hoel DG: Studies of the mortality of A-bomb survivors. Mortality, 1950-1985: Part 3.
Noncancer mortality based on revised doses (DS86).Radiation Research 130:249-266,92

Wong FL, Yamada M, Sasaki H, Kodama K, Akiba S, Shimaoka K, Hosoda Y:
Non-cancer disease incidence in atomic-bomb survivors, 1958-1986. Radiation Research 135:418-430, 1993

Kodama K: Cardiovascular disease in atomic-bomb survivors, 5(4):3-4, 1994.
Radiation Effects Research Foundation, Hiroshima.

Life Span Study (LSS)

[RERF often changes site pages, if unable to access this study at this page, please inform webmaster.]

This study has been referred to as the “extended LSS,” “the extended ST100,” “the LSS extended,” “LSS-E85”, “the ST100,” and other variations of these terms, but it is probably best referred to as simply the Life Span Study.

  • Study objective
    To study whether the life span and causes of death among atomic-bomb survivors differ from those of unexposed individuals. This research program includes both incidence and mortality studies based on vital-statistics surveys, death-certificate information, and other sources.

Following is a list of Life Span Study (LSS) report titles.

  • LSS Report 12
    Part 1. Cancer: 1950-1990
  • LSS Report 11
    Part 1. Comparison of risk coefficients for site-specific cancer mortality based on the DS86 and T65DR shielded kerma and organ doses
    Part 2. Cancer mortality in the years 1950-1985 based on the recently revised doses (DS86)
    Part 3. Noncancer mortality, 1950-1985, based on the revised doses (DS86
    LSS Report 10
    Part 1.
     Cancer mortality among A-bomb survivors in Hiroshima and Nagasaki, 1950-1982
  • LSS Report 9
    Part 1. Cancer mortality among atomic bomb survivors, 1950-1978
    Part 2. Mortality from causes other than cancer among atomic bomb survivors, 1950-1978
    Part 3. Tumor Registry data, Nagasaki, 1959-1978
  • LSS Report 8: Mortality experience of atomic bomb survivors, 1950-1974
  • LSS Report 7: Mortality experience of A-bomb survivors, 1970-1972, 1950-1972
  • LSS Report 6: Mortality among atomic bomb survivors, Hiroshima-Nagasaki, 1950-1970
  • LSS Report 5: Mortality and radiation dose, October 1950-September 1966
  • LSS Report 4: Mortality in atomic bomb survivors by age cohorts, 1950-1959
  • LSS Report 3: Mortality, October 1950-September 1960
  • LSS Report 2: Mortality in selection I and II, October 1950-September 1959
  • LSS Report 1: Description of the study, October 1950-June 1958

Where to Send Questions or Comments
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